The cell envelope subtilisin-like proteinase is a virulence determinant for <Emphasis Type="Italic">Streptococcus suis</Emphasis> |
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| Authors: | Laetitia Bonifait Maria de la Cruz Dominguez-Punaro Katy Vaillancourt Christian Bart Josh Slater Michel Frenette Marcelo Gottschalk Daniel Grenier |
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| Institution: | 1.Groupe de Recherche en écologie Buccale,Faculté de Médecine Dentaire, Université Laval,Quebec City,Canada;2.Groupe de Recherche sur les Maladies Infectieuses du Porc,Faculté de Médecine Vétérinaire, Université de Montréal,Saint-Hyacinthe,Canada;3.The Royal Veterinary College,Hatfield,UK |
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| Abstract: | Background
Streptococcus suis is a major swine pathogen and zoonotic agent that mainly causes septicemia, meningitis, and endocarditis. It has recently
been suggested that proteinases produced by S. suis (serotype 2) are potential virulence determinants. In the present study, we screened a S. suis mutant library created by the insertion of Tn917 transposon in order to isolate a mutant deficient in a cell surface proteinase. We characterized the gene and assessed the
proteinase for its potential as a virulence factor. |
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