Hydrogen Bonding Interactions of Liposomes Simulating Cell-Cell Recognition. A Review

Amphiphiles bearing polar heads with the property to form hydrogen bond(s) exhibit unique organizational and aggregational behaviour. Thus appropriate amphiphilic molecules assemble and form liposomes, which further interact through hydrogen bonding with complementary molecules or liposomal counterparts affording larger and more elaborated aggregates. A number of examples are demonstrating the interaction mode of liposomes and of associated phenomena as related to the structural features of the supramolecular aggregates obtained. The recognition between cells incorporating recognizable amphiphiles in their membranes has shown similarities to the analogous interactions between liposomes. Thus molecular recognition between liposomes can be used in modeling recognitions occurring between cells. Designed experiments in this area can support the Lipid World Model proposed for the origin of life.