Deformation-Driven,lethal damage to cancer cells |
| |
Authors: | Leonard Weiss |
| |
Institution: | 1. Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY
|
| |
Abstract: | Direct and indirect, in vivo and in vitro observations are in accord with the hypothesis that as a consequence of their deformation
within capillaries, cancer cells undergo sphere-to-cylinder shape-transformations that create a demand for increased surface
area. When this demand cannot be met by apparent increases in surface area accomplished by nonlethal, surface “unfolding,”
the cell surface membrane is stretched; if expansion results in more than a 4% increase in true surface area, the membrane
ruptures, resulting in cancer cell death.
It is suggested that this deformation-driven process is an important factor in accounting for the rapid death of circulating
cancer cells that have been trapped in the microvasculature. Therefore, this mechanism is thought to make a significant contribution
to metastatic inefficiency by acting as a potent rate-regulator for hematogenous metastasis. |
| |
Keywords: | Index Entries" target="_blank">Index Entries Metastasis microvasculature cell deformation cell death cancer cells |
本文献已被 SpringerLink 等数据库收录! |
|