Synthesis of natural-product-based compound libraries |
| |
Authors: | Wessjohann L A |
| |
Institution: | Vrije Universiteit Amsterdam, Bioorganic Chemistry - FEW/OAC, NL-1081 HV, Amsterdam, The Netherlands. wessjohn@chem.vu.nl |
| |
Abstract: | Natural products cover a diversity space not yet available from synthetic libraries, with an unrivalled success rate as drug leads. The combinatorial synthesis of non-oligomeric natural-product-based libraries, however, is still limited to few examples because access to easily modified units strongly depends on the availability of a core structure either from a natural source, or through a suitable synthetic route. Only a few resourceful groups have managed the latter approach for more demanding multifunctional natural drug leads, such as epothilones. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|