Cytotoxic ent-kaurene diterpenoids from Isodon phyllostachys |
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| Authors: | Li Xian Xiao Weilie Pu Jianxin Ban Lili Shen Yunheng Weng Zhiying Li Shenghong Sun Handong |
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| Institution: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Longquan Road, Heilongtan 610, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China. |
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| Abstract: | ent-Kaurene diterpenoids, phyllostachysins D-H (1-5), together with nine known compounds, rabdoloxins A-B (6-7), rabdoinflexin B (8), amethystoidin A (9), rabdokunmin D (10), macrocalyxin E (11), 5,7-dihydroxy-4'-hydroxylflavone (12), oleanolic acid (13) and daucosterol (14), were isolated from aerial parts of Isodon phyllostachys. Structures were elucidated on the basis of spectroscopic methods, especially using 2D-NMR spectroscopic analyses. All ent-kaurenoids were tested for their cytotoxic effects against K562 cells. Compound 9 was the most potent with an IC50 value of 0.69 microg/ml. |
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| Keywords: | Isodon phyllostachys Labiatae ent-Kaurenoids Phyllostachysins D-H Cytotoxic effect |
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