Intrathecal adenosine A1 receptor agonist attenuates hyperalgesia without inhibiting spinal glutamate release in the rat |
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| Authors: | Yamamoto Syuichiro Nakanishi Osamu Matsui Tomohiro Shinohara Noriyuki Kinoshita Hiroyuki Lambert Clinton Ishikawa Toshizo |
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| Institution: | (1) Department of Laboratory Sciences, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan;(2) Department of Dental Anesthesiology, Kyusyu Dental College, Kitakyusyu, Fukuoka, Japan;(3) Department of Anesthesiology, Wakayama Red Cross Medical Center, Wakayama, Japan |
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| Abstract: | The analgesia effects of intrathecal adenosine A1 receptor agonist, R-PIA, on the hyperalgesia and CSF-glutamate release after formalin injection into the rat paw were evaluated. R-PIA significantly and dose-dependently attenuated increases in flinching behavior, and this attenuating effect was reversed by the adenosine A1 receptor antagonist, aminophylline. Morphine blocked flinchs, however MK-801 partially abolished. The increase in CSF-glutamate release evoked by formalin stimulation was inhibited by morphine but not by either R-PIA or MK-801. These findings suggest that the intrathecal adenosine A1 receptor agonist provokes analgesic effect via the postsynaptic action independent of an effect upon spinal glutamate release. |
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| Keywords: | hyperalgesia CSF-glutamate release adenosine |
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