Stimulation by oxytocin of prostaglandin F levels in uterine venous effluent in pregnant and puerperal sheep |
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Authors: | MD Mitchell APF Flint AC Turnbull |
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Institution: | Nuffield Department of Obstetrics and Gynaecology John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK |
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Abstract: | The purpose of this work was to investigate the effect of oxytocin on prostaglandin F (PGF) concentrations in uterine venous effluent. PGF was measured in utero-ovarian venous plasma from three pregnant ewes and in posterior vena caval plasma, from two puerperal ewes, during oxytocin administration. Oxytocin caused 4.9 – 5.3-fold increases in PGF concentrations in the pregnant animals, the response increasing towards term. In the puerperal animals oxytocin caused 3.7 – 17.2-fold increases in PGF concentrations with a marked latency in the response. Measurement of uterine activity and progesterone and total unconjugated oestrogen concentrations indicated that neither uterine contractions nor a decreased uterine blood flow accounted for the elevated PGF levels stimulated by oxytocin. |
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