Ultimobranchial gland of the domestic fowl |
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Authors: | F. Treilhou-Lahille F. Lasmoles J. Taboulet J. P. Barlet G. Milhaud M. S. Moukhtar |
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Affiliation: | (1) E.R.A. 902, Laboratoire de Biologie-Vertébrés, Université Paris-XI, Centre d'Orsay, France;(2) L.A. 163 C.N.R.S. et INSERM U113, Service de Biophysique, C.H.U. Saint Antoine, Paris, France;(3) I.N.R.A., Theix, Beaumont, France;(4) Laboratoire de Biologie-Vertébrés, Université Paris-Sud, Bâtiment 441, 91405 Orsay Cedex, France |
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Abstract: | Summary The ultimobranchial gland (UBG) of birds is particularly rich in calcitonin, the hypocalcaemic hypophosphataemic hormone, that is secreted by the C-cells of the mammalian thyroid. The principal cells of the UBG have a striking resemblance with the mammalian C-cells, i.e., they possess small intracytoplasmic dense-core secretory granules, 150–300 nm in diameter. The gland also contains a second, morphologically distinct, endocrine cell type with larger granules, 500–800 nm in diameter. A sensitive immunocytochemical reaction was developed with the use of antibodies against salmon calcitonin. By means of this technique the presence of calcitonin-immunoreactive molecules was demonstrated in both secretory cell types of the UB gland of the chicken. This gland can thus be considered as a homogeneous calcitonin-producing tissue. Whether the secretory products are identical is discussed and differences in the secretory pathways are suggested. |
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Keywords: | Ultimobranchial gland Endocrine cell types Calcitonin Secretory processs Chicken |
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