支气管哮喘急性发作期超敏C-反应蛋白、白细胞、中性粒细胞比例检测的意义及比较

探讨超敏C-反应蛋白（hs-CRP）、血白细胞总数（WBC）、中性粒细胞比例（N％）在支气管哮喘（简称哮喘）急性发作期诊治中的临床意义。方法：分析60例患者治疗前及自觉症状缓解时hs—CRP、WBC、N％动态变化情况，观察上述指标在急性发作期的阳性率以及自觉症状缓解时的阴性率。结果：①hs-CRP、N％、WBC在自觉症状缓解时均明显低于哮喘急性发作期（P〈0．05）；②哮喘患者急性发作期hs—CRP、N％阳性率均高于WBC阳性率，且与后者比较均具有统计学差异（P〈0．05）；③哮喘患者经治疗自觉症状缓解时hs-CRP、WBC阴性率均高于N％阴性率，且与后者比较均具有统计学差异（P〈0．05）。结论-血清hs-CRP既可作为哮喘患者急性发作期感染的敏感指标，又是反映急性发作期治疗效果的早期评判指标，比WBC、N％更迅速、敏感。

Clinical Significance of Detection of High Sensitivity C-reactive Protein, WBC,Neurocyte Percent in Serum in Acute Asthmatic Period

Objective： To investigate the clinical significance of hs-CRP, WBC, Neurocyte Percent （N%）in the diagnosis and treatment in acute asthmatic period. Methods： The changes of serum hs-CRP, WBC count, N% in 60 patients with asthma in acute episode period before therapy and when feeling symptoms relief after therapy were retrospectively analyzed and summarized ;and their positive rate in acute episode period and their negative rate when feeling symptoms relief was observed . Results：（1） The levels of hs-CRP,WBC count,N% in patients with asthma when feeling symptoms relief is obviously lower than that in acute episode period（ P 〈 0. 05）; （2） The positive rate of hs-CRP and N% in patients with asthma in acute episode period is higher than that of WBC, and the difference was obvious （P〈0.05）; （3） the negative rate ofhs-CRP and WBC count in patients with asthma when feeling symptoms relief after therapy is higher than that of N%, and the difference was obvious （ P〈0.05）; Conclusion： Serum hs-CRP can be as a sensitive index in detecting the infection in patients with asthma in acute episode period, also be an index in early evaluating the therapeutic efficacy of asthma in acute episode period, and is more sensitive and quicker compared with WBC,N%.