AMI患者血浆NT—proBNP水平与心肌缺血及预后关系的研究

目的：探讨急性心肌梗死（AMI）患者血浆N末端B型尿钠肽前体（NT-proBNP）的水平与心肌缺血及预后的关系。方法：98例急性心肌梗死患者根据患者是否行直接PCI手术治疗，分为PCI手术治疗组和非PCI治疗组，观察缺血改善情况与NT-proBNP水平的关系，同时根据治疗后NT-proBNP的水平分为三组，A组NT-proBNP〈125pg／ml、B组125pg／ml≤NT-proBNP〈450pg／ml、C组NT-proBNP≥450pg／ml，观察NT—proBNP的水平与预后的关系。结果：行PCI组NT—proBNP的水平下降程度（438．3±134．5）明显高于未行PCI组者（158．6±146．1，P〈0．05），MACE的发生情况C组明显高于A组（P=0．006〈0．01），也高于B组（P=0．028〈0．05），A组与B组相比，B组的MACE发生率有上升的趋势，但是无统计学意义（P=0．432〉0．05）.结论：急性心肌梗死患者早期血浆NT-proBNP的水平在一定程度上可以反应心肌的缺血程度，且与患者的预后成明显的负相关。

Relationship between Plasma NT-proBNPLevels and Myocardial Ischemia and Prognosis in AMI Patients

Objective： To study the relationship between plasma N-terminal pro-B-type natriuretic （NT-proBNP） levels and myocardial ischemia, prognosis in Acute myocardial infarction （AMI） patients. Methods： According to the patients whether underwent primary PCI operation ,98 AMI patients were divided into surgical PCI treatment group and the non-PCI treatment group, to observe the association improved schemia situation with NT-proBNP level, meanwhile according to the levels of the NT-proBNP after treatment ,the patients were divided into three groups, including A group（NT-proBNP〈 125pg/ml）, B group （125pg/ml ≤NT-proBNP〈450pg/ml） and C group （NT-proBNP≥450pg/ml）, to observe the relationship between the levels of the NT-proBNP and prognosis. Results： The NT-proBN- P levels in PCI treatment group decreased significantly （438.3±134.5）compared with non-PCI treatment group （158.6± 146.1, P 〈0.05）, The incidence of MACE in group C was significantly higher than group A （P = 0.006 〈0.01）, also higher than the B group（P=-0.028 〈 0.05 ）, The incidence of MACE in group B was higher than group A, but the two groups no significant difference in meaning. Conclusions： AMI patients with early plasma NT-proBNP levels Can reflect the degree of myocardial ischemia to some extent, and have a significant negative correlation to prognosis of the patient.