肝细胞肝癌E-Cadherin蛋白的表达及其对判断肝癌肝移植疗效的意义

目的：探讨E-Cadherin蛋白在肝细胞肝癌组织中的表达及其对判断肝癌肝移植患者预后的价值。方法：选择肝细胞肝癌行全肝移植患者68例,应用免疫组化方法检测其切除的肝癌组织和癌旁正常肝组织中E-Cadherin蛋白的表达情况,并对患者进行移植术后随访,分析E-Cadherin蛋白表达与肝癌肝移植患者预后的关系。结果：肝癌组织中E-Cadherin蛋白阳性表达率明显低于癌旁组织（P〈0.01）。经Logrank检验分析显示,E-Cadherin蛋白低表达组移植后的无瘤生存率明显低于E-Cadherin蛋白高表达组（P〈0.01）。多因素Cox回归分析显示,E-Cadherin蛋白表达是影响肝细胞肝癌患者肝移植术后肝癌复发的独立预后因素之一。结论：E-Cadherin蛋白表达是一个预测肝细胞肝癌患者肝移植预后的重要因子。

Relationship Between E-Cadherin Expression and Prognosis of Liver Transplant Patients with Hepatocellular Carcinoma

Objective： To investigate the expression of E-Cadherin in patients with human hepatocellular carcinoma（HCC）,and evaluate the prognosis of patients after liver transplantation.Methods： The expression of E-Cadherin protein was detected with immunohistochemical analysis in 68 cases of HCC.With follow up,the prognostic value of E-Cadherin in HCC patients undergoing liver transplantation were explored.Results： The positive expression rates of E-Cadherin protein in tumor tissues were significantly lower than that in pericarcinoma tissues in HCC（P0.01）.The relapse-free survival rate was significantly lower in E-Cadherin positive group than that in E-Cadherin negative group.Multivariate analysis with the Cox proportional hazards model showed that E-Cadherin protein was an independent prognostic factor for HCC patients after liver transplantation.Conclusions： The expression of E-Cadherin protein is an independent prognostic factor for HCC patients undergoing liver transplantation.