NGF及其受体TrkA在子宫腺肌病中的表达及与痛经的关系

目的：研究NGF及其受体TrkA在子宫腺肌病患者的异位内膜与在位内膜组织的表达情况及与痛经的关系。方法：采用免疫组化MaxVision法检测子宫腺肌病异位内膜（30例）、在位内膜（30例）、正常子宫内膜（19例）标本中NGF、TrkA蛋白的表达,分析其表达差异及与痛经的关系。结果：①子宫腺肌病异位内膜组NGF、TrkA表达显著高于正常内膜组（P〈0.01）,在位内膜组NGF、TrkA表达显著高于正常内膜组（P〈0.01）,子宫腺肌病异位内膜组NGF、TrkA表达与在位内膜组无显著差异。②子宫腺肌病异位内膜组NGF、TrkA表达与痛经强度评分呈正相关（相关系数r=0.637,P=0.000;r=0.662,P=0.000）。结论：NGF及其受体TrkA在子宫腺肌病中高表达可能参与子宫腺肌病发病机制,而且可能与痛经有关。

The expression of NGF and TrkA in patients with adenomyosis and its relationship with dysmenorrhea

Objective：To investigate the expression of NGF and TrkA in the ectopic and eutopic endometrium of women with adenomyosis and their relationships with dysmenorrhea.Methods：Immunohistochemistry was used to test the expression of NGF and TrkA in the ectopic endometrium of adenomyosis group（30 cases）,the eutopic endometrium of adenomyosis group（30 cases）,and the endometrium of normal group（19 cases）,and to examine the correlations between their expression levels and the pain intensity.Results：① The expression levels of NGF and TrkA in the ectopic and eutopic endometrium of adenomyosis group were higher than normal con-trols（P0.01）,No difference of NGF and TrkA expression levels was found between ectopic and eutopic endometrium of adenomyosis group.There were positive correlations between the expression levels of NGF and TrkA in ectopic endometrium of adenomyosis and the pain intensity（r = 0.637,P=0.000;r = 0.662,P=0.000）.Conclusion：NGF and TrkA express highly in adenomyosis,and they may play an important role in the pathogenesis and the development of adenomyosis,and they may be correlated to the dysmenorrhea in adenomyosis.