红景天苷对高原缺氧大鼠认知功能障碍的治疗作用及其可能机制

目的：探讨红景天苷（Sal）对高原缺氧大鼠认知功能障碍的治疗作用及其可能机制。方法：将30只成年雄性SD大鼠随机分为健康对照组、模型组（Model组）、Sal[按体重1g／（kg·d）]治疗组（sal组）。采用Morris水迷宫实验方法捡测缺氧后大鼠学习记忆功能变化，同时检测脑组织匀浆中超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH—PX）、谷胱甘）lk（GSH）、丙二醛（MDA）的水平。结果：（1）模型组大鼠寻找平台的潜伏期明显长于对照组，具有统计学意义（P〈0．05），Sal组寻找平台的潜伏期相对于模型组显著缩短（P〈0．05）。撤离平台后，模型组大鼠在平台所在象限的停留时间明显短于对照组（P〈0．05），Sal治疗后大鼠在平台所在象限的停留时间较模型组显著延长（P〈0．05）。（2）模型组SOD、GSH—PX、GSH显著下降，MDA明显增高，Sal干预组SOD、GSH．PX、GSH显著增高，而MDA明显下降，具有统计学意义（P〈O．05）。结论：Sal可改善高原缺氧大鼠认知功能，其可能机制是通过减轻海马区的氧化应激反应减轻海马区的损伤，从而实现改善认知功能。

Salidroside for Hypobaric Hypoxia-Induced Cognitive Deficits in Rats and Its Possible Mechanism

Objective： To investigate the effects ofsalidroside （Sal） on cognitive deficits induced by hypobaric hypoxia and to in- vestigate the possible mechanism in terms of oxidative stress in hippocampus. Methods： A total of 30 male Sprague-Dawley rats （200± 20g） were randomly divided into three groups： （n =10 in each group）： Control group, Model group and Sal group. Severe cognitive deficits were tested by the water maze task. The content of Glutathione（GSH） and Maleic Dialdehyde（MDA） were measured; The activity of Superoxide Dismutase （SOD） and glutathione peroxidase （GSH-PX）in the homogenate of Hippocampus were detected. Results： Hypo- baric hypoxia can cause severe cognitive deficits, and salidroside could attenuate hypobaric hypoxia-induced cognitive deficits. Biochemical experiments revealed that hypobaric hypoxia can significantly increase MDA, decrease GSH and the activities of SOD and GSH-PX in the homogenate of Hippocampus, which can be reversed by salidroside. Conclusions： Salidroside exhibits therapeutic potential for hypobaric hypoxia-induced cognitive deficits, which may be related to its anti-oxidative stress actions in hippocampus.