南京迈皋桥社区人群甲状腺功能减退症的流行研究

目的：研究南京迈皋桥社区人群甲状腺功能减退症（甲减）的流行特征。方法：采用随机整群抽样方法按全国城市人口普查的年龄构成在南京迈皋桥地区抽取≥20岁,5年之内不会动迁的常驻社区居民。采集空腹血清1540份,测定促甲状腺激素（TSH）、三碘甲状腺游氨酸（FT3）、游离甲状腺素（FT4）,甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TGAb）。结果：（1）南京迈皋桥地区社区人群的临床甲减和亚临床甲减的患病率分别为0.45%,3.96%。（2）男性亚临床甲减的患病率低于女性（P〈0.01）,临床甲减患病率男女之间无显著差异（P〉0.05）。（3）男性不同年龄段间临床甲减和亚临床甲减的患病率均无差异（P〉0.05）。女性临床甲减的患病率有随年龄增加而升高的趋势（P=0.02）,50岁以上女性亚临床甲减患病率显著增高（P〈0.01）。结论：与临床甲减相比,南京社区人群的亚临床甲减患病率显著升高,应加强对其随访和早期防治。

Epidemic Character of Hypothyroidism at a Community of Maigaoqiao in Nanjing City

Objective：To investigate the prevalence of hypothyroidism in a community of Maigaoqiao at Nanjing.Methods：Com-munity-living subjects,aged 20 years or older,who had lived in Maigaoqiao at Nanjing for at least 5 years were sampled by a randomized clustered sampling method based on national population census data.Fasting serum were sampled from 1540 subjects and thyroid stimu-lating hormone（TSH）,free thyroxine（FT4）,free triiodothyronine（FT3）,thyroid peroxidase antibodie（TPOAb）,and thyroglobulin anti-bodie（TgAb） were measured.Results：（1） The prevalences of overt hypothyroidism and subclinical hypothyroidism were 0.45%,3.96% respectively in total population.（2） The prevalence of subclinical hypothyroidism was significantly higher in females than in males（P0.01）,but not overt hypothyroidism（P0.05）.（3） The prevalences of overt hypothyroidism and subclinical hypothyroidism were not signif-icantly different among age groups in males（P0.05）.In females,The prevalence of overt hypothyroidism was significantly increased with advancing age（P=0.02）while the incidence of subclinical hypothyroidism was significantly higher in aged 50 or older groups（P0.01）.Conclusions：Comparing with overt hypothyroidism,subclinical hypothyroidism presented higher prevalence in Maigaoqiao at Nan-jing,and more attention should be paid to the follow-up and diagnosis of subclinical hypothyroidism.