| 人脑星形细胞瘤中p53，Fas／FasL的表达及其与凋亡关系的研究 |
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| 引用本文： | 张丽红,齐蕾,单丽辉,柴翠翠,韩伟,王立峰. 人脑星形细胞瘤中p53，Fas／FasL的表达及其与凋亡关系的研究[J]. 生物磁学, 2011, 0(18): 3501-3503,3539 |
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| 作者姓名： | 张丽红 齐蕾 单丽辉 柴翠翠 韩伟 王立峰 |
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| 作者单位： | [1]哈尔滨医科大学附属第一临床医院放射科,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属第一临床医院病理科,黑龙江哈尔滨150001 |
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| 基金项目： | 基金项目：哈尔滨市科技创新人才专项资金项目（RC2010XK004048） |
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| 摘 要： | 目的：探讨细胞凋亡在星形细胞瘤中的作用及其与p53、Fas和Fas配体（Fas ligand，FasL）的关系。方法：对43例星形细胞瘤的标本分别进行HE染色，TUNEL及免疫组化分别标记p53，Fas和FasL。结果：高级别肿瘤和低级别肿瘤间的凋亡无显著差异（P〉0．05）。高级别星形细胞瘤的p53，Fas和FasL的表达均显著高于低级别肿瘤（P均〈0．05）。结论：突变型p53可作为评价星形细胞瘤生物学行为的参考指标。与低级别星形细胞瘤相比，高级别肿瘤中的细胞凋亡受到了抑制，且Fas与FasL的过表达对细胞凋亡可产生明显影响。
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| 关 键 词： | 星形细胞瘤 细胞凋亡 p53 Fas／FasL |
The expression of p53, Fas/FasL and their correlation with apoptosis in human brain astrocytomas |
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| ZHANG Li-hong,QI Lei,SHAN Li-hui,CHAI Cui-cui,HAN Wei,WANG Li-feng. The expression of p53, Fas/FasL and their correlation with apoptosis in human brain astrocytomas[J]. Biomagnetism, 2011, 0(18): 3501-3503,3539 |
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| Authors: | ZHANG Li-hong QI Lei SHAN Li-hui CHAI Cui-cui HAN Wei WANG Li-feng |
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| Affiliation: | 1 Department of radiology , The First Hospital of the Harbin Medical University, 150001, Harbin, China; 2 Department of Pathology, The First Hospital of the Harbin Medical University, 150001, Harbin, China) |
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| Abstract: | Objective： To investigate the role of apoptosis in the progression of astrocytomas and its correlation with the expression of p53 and Fas/FasL. Methods： Histopathological analysis, TUNEL labeling and immunohistochemical staining of p53 and Fas/FasL. Results： Apoptosis was not significantly different in the two groups（ P〉0.05 ）; Expression of p53, Fas and FasL was significantly higher in the high-grade astrocytomas than the low-grade ones （P〈0.05）. Conclusion： p53 can serve as an informative parameter to evaluate the biological behavior of astrocytomas, Apoptosis may be suppressed in high-grade astrocytomas, the expression of the Fas/FasL aslo exert remarkable influence on apoptosis in the astrocytomas. |
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| Keywords: | Astrocytoma Apoptosis p53 Fas/FasL |
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