| IL-6、IL-23在肠易激综合征患者肠黏膜的表达及意义 |
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| 引用本文： | 刘修波,卫红军,张巍巍,王青. IL-6、IL-23在肠易激综合征患者肠黏膜的表达及意义[J]. 生物磁学, 2011, 0(7): 1250-1252,1288 |
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| 作者姓名： | 刘修波 卫红军 张巍巍 王青 |
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| 作者单位： | 青岛大学医学院附属青岛市市立医院,山东青岛266071 |
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| 摘 要： | 目的：研究肠易激综合征（irritable bowel syndrome,IBS）患者回肠末端及升结肠黏膜组织中白介素-6（interleukin-6,IL-6）、白介素-23（interleukin-23,IL-23）的表达。方法：70例腹泻型和40例便秘型IBS患者及30例健康人,用免疫组化法测定回肠末端及升结肠肠黏膜中IL-6及IL-23水平。结果：IL-6及IL-23在腹泻型及便秘型IBS患者回肠末端及升结肠的表达均高于对照组（P〈0.05）。结论：IBS患者回肠及升结肠黏膜炎性细胞因子表达水平升高,可能与IBS症状有关。
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| 关 键 词： | 肠易激综合征 细胞因子 白介素 |
Expression of IL-6 and IL-23 in Bowel Mucosa of Patients with Irritable Bowel Syndrome |
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| LIU Xiu-bo,WEI Hong-jun,ZHANG Wei-wei,WANG Qing. Expression of IL-6 and IL-23 in Bowel Mucosa of Patients with Irritable Bowel Syndrome[J]. Biomagnetism, 2011, 0(7): 1250-1252,1288 |
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| Authors: | LIU Xiu-bo WEI Hong-jun ZHANG Wei-wei WANG Qing |
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| Affiliation: | △ (Qingdao Municipal Hospital Affiliated to Qingdao University Medical College,Qingdao,266071,Shandong,China) |
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| Abstract: | Objective：To study expression of interleukin（IL）-6 and IL-23 in the mucosa of ileum as well as in the ascending colon.Methods：The ileum and ascending colon from 70 cases of diarrhea type of IBS,40 cases of constipation group type of IBS and 30 cases of healthy volunteers as control were collected and detected the IL-6 and IL-23 expression using immunohistochemistry.Results：Both diarrhea group and constipation group,IL-6 and IL-23 were highly expressed in the mucosa of ileum and ascending colon than con-trol group（P0.05）.Conclusion：The highly expression of IL-6 and IL-23 in the mucosa of ileum and ascending colon may be related to symptoms of IBS. |
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| Keywords: | Irritable Bowel Syndrome Cytokines Interleukin |
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