阿托伐他汀改善冠心病患者血管内皮功能的临床研究

目的：观察短期阿托伐他汀治疗对高胆固醇血症的冠心病患者血管内皮功能的影响。方法：78例高胆固醇血症患者每日口服阿托伐他汀共8周，服药前后测量患者血清的总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（IDIrC）、高密度脂蛋白胆固醇（HDL-C）和氧化低密度脂蛋白（ox-LDL）以及NO值，并用彩色多普勒超声测定反应性充血时肱动脉内径的变化。结果：高胆固醇血症患者经阿托伐他汀8周治疗后，血清的TC、TG、LDL-C和ox-LDL明显下降，血清的HDL-C以及NO值明显增加，反应性充血时肱动脉内径扩张程度明显增加，这些与治疗前相比有明显差异。结论：阿托伐他汀治疗能使高胆固醇血症的冠心病患者血脂改变,NO值增加，血管内皮功能改善。

The Effects of Atorvastatin on Brachial Artery Endothelial Function in Patients with Coronary Heart Disease

Objective： To study the effects of atorvastatin cholesterol-lowering therapy on vascular endothelial funetion in patients with coronary heart disease（CHD）. Methoeds： A total of 78 patients took atorvastatin daily for 8 weeks. Vascular endothelial function in form of flow-mediated dilatation was assessed in the brachium artery by high-resolution ultrasound technique and the levels of total cholesterol（TC）, triglyceride （TG）,low-density lipoprotein cholesterol（LDL-C）, oxidatively modified low-density lipoprotein（ox-LDL）, high-density lipoprotein cholesterol （HDL-C） and nitric oxide （NO） were assayed before and after 8 weeks treatment. Results： After 8 weeks atorvastatin treatment, vascular endothelial function were obviously improved and the levels of HDL-C and NO were markedly increased compared with that before treatment （ P 〈 0. 01）, while TC, TG, LDL-C and ox-LDL were markedly decreased （P 〈 0. 01）. Conclusion：The cholesterol-lowering therapy with atorvastatin could improve vascular endothelial function of CHD patients with high serum cholesterol.