| 蛋白质表面氨基酸特性研究进展 |
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| 引用本文： | 荆艳,宋晓峰. 蛋白质表面氨基酸特性研究进展[J]. 生物磁学, 2011, 0(10): 1991-1994 |
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| 作者姓名： | 荆艳 宋晓峰 |
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| 作者单位： | 南京航空航天大学生物医学工程系,江苏南京210016 |
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| 基金项目： | 江苏省自然科学基金资助（BK2010500） |
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| 摘 要： | 分布在蛋白质分子表面的暴露于溶剂的氨基酸所具有的一些特性对蛋白质的折叠和聚合过程、蛋白质一蛋白质相互作用以及蛋白质的功能具有重要影响。本文分析了蛋白质表面氨基酸在疏水性、保守性、静电势及结构方面的一些特性，阐述了近年来国际上利用这些特性对蛋白质一蛋白质相互作用界面进行预测的方法，最后介绍了几款预测蛋白质表面氨基酸的软件。
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| 关 键 词： | 蛋白质表面特性 蛋白质相互作用界面 预测方法 |
Progress in Properties of Amino Acids on Surface of Protein Molecules |
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| JING Yah,SONG Xiao-feng. Progress in Properties of Amino Acids on Surface of Protein Molecules[J]. Biomagnetism, 2011, 0(10): 1991-1994 |
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| Authors: | JING Yah SONG Xiao-feng |
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| Affiliation: | (Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, China) |
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| Abstract: | The properties of the surface amino acids that exposed to the solvent can influence the fold and polymerization processes, protein-protein interaction and the function of proteins. This paper analyzes the properties of surface amino acids such as hydrophobicity, conservation, electrostatic potential and structural properties. Also, the methods using these properties to predict the interfaces between two interacting proteins in the international filed were reviewed. Finally we introduced several softwares of predicting surface amino acids. |
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| Keywords: | The properties of protein surface Protein-protein interface Prediction methods |
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