| 丹参酮IIA对大鼠移植性肝癌的抑制作用 |
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| 引用本文： | 王晓露,解方为,陈曦,张霞,欧阳学农.丹参酮IIA对大鼠移植性肝癌的抑制作用[J].生物磁学,2011(11):2062-2064. |
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| 作者姓名： | 王晓露 解方为 陈曦 张霞 欧阳学农 |
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| 作者单位： | [1]南京军区福州总医院肿瘤科,福建福州350025 [2]江苏省中医院肿瘤内科,江苏南京210029 |
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| 基金项目： | ”十一五”军队中医药研发推广专项课题基金资助（2006051002） |
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| 摘 要： | 目的：观察丹参酮IIA对大鼠移植性肝癌的抑制作用。方法：将sD大鼠随机分为假手术组、模型组、丹参酮IA高、低剂量组。各组动物于移植术后12d处死。分离肿瘤测量其体积，reahimeRT．PCR法和western blot法检测肿瘤组织中HMGB1、VEGFmRNA和蛋白的表达。结果：丹参酮IIA能明显降低肿瘤体积，降低肿瘤组织中HMGBl、VEGFmRNA和蛋白的表达。结论：丹参酮IIA能抑制大鼠移植性肝癌的生长，其机制可能与抑制HMGB1、VEGF表达有关。
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| 关 键 词： | 丹参酮IIA HMGB1 VEGF |
The Inhibitive Effect of Tanshinone IIA on Implanted Hepatoma in Rats |
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| Institution: | WANG Xiao-lu, XIE Fang-wei, CHEN Xi, ZHANG Xia, OUYANG Xue-nong (I Department of Oncology, Fuzhou General Hospital of Nanjing Command, Fuzhou 350025; 2 Department of Oncology, Hospitals of Traditional Chinese Medicine of Jiangsu province, Nanjing 210029) |
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| Abstract: | Objective： To study the effect of Tanshinone IIA on implanted hepatoma in rats. Method： Sprague Dawley rats were divide into normal group, sham operated group and two Tanshinone IIA groups. Contents of HMGB1, VEGF protein and mRNA were detected by immunohistochemical and real-time PCR methods, respectivly. Result： In Tanshinone IIA groups, Contents of HMGB1, VEGF protein and mRNA were decreased markedly. Conclusion： Tanshinone IIA could inhibit the implanted hepatoma in rats. This maybe be concerned with that it could inhibit the expression of HMGB 1 and VEGF in the implanted hepatoma in rats. |
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| Keywords: | Tanshinone IIA HMGB 1 VEGF |
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