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丙型肝炎病毒感染与肝细胞癌相关关系的研究进展
引用本文:李曼,冯德云. 丙型肝炎病毒感染与肝细胞癌相关关系的研究进展[J]. 生物磁学, 2011, 0(9): 1797-1800
作者姓名:李曼  冯德云
作者单位:中南大学湘雅医学院病理学系,湖南长沙410013
基金项目:国家自然科学基金资助(30901452)
摘    要:世界上有数亿的人口患有丙型肝炎,而丙型肝炎病毒(HCV)的感染易转为慢性,引起肝细胞炎性坏死及再生,导致肝纤维化、硬化甚至肝细胞癌(HCC),是危害人类健康的一个重要卫生问题。HCV的感染可导致HCC的发生,但HCV相关性HCC的发生机制尚不清楚。免疫逃避机制是感染慢性化的一个重要原因,病毒通过其基因组编码的蛋白使肝细胞发生转化,可能是肝细胞癌变的重要机制。

关 键 词:丙型肝炎病毒  肝细胞肝癌  发生机制

Relationship Between HCV Infection and Hepatocarcinoma
LI Man,FENG De-yun. Relationship Between HCV Infection and Hepatocarcinoma[J]. Biomagnetism, 2011, 0(9): 1797-1800
Authors:LI Man  FENG De-yun
Affiliation:(Department of Pathology, Xiangya school of medical, Central South University, Changsha, 410013, China)
Abstract:There is hundreds of millions of population in the world suffering from hepatitis C,and this is an important health problem to human. Hepatitis C virus(HCV) infection prone to chronic inflammation, and cause injury, necrosis and regeneration, leading to liver fibrosisand even hepatocellular carcinoma(HCC).HCV infection can lead to the occurrence of HCC,butHCV-relatedpathogenesis of HCC has been in the study. Immune escape mechanism is an important reason for chronic infection, and the virus proteins may be the im- portant mechanism for malignant transformation.
Keywords:HCV  Hepatocellular carcinoma  Mechanism
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