| 多药耐药基因1C3435T多态性与癫痫耐药的关联性研究 |
| |
| 引用本文： | 王小燕,林若飞,史道华,白志峰,杨朋范.多药耐药基因1C3435T多态性与癫痫耐药的关联性研究[J].生物磁学,2011(14):2717-2719. |
| |
| 作者姓名： | 王小燕 林若飞 史道华 白志峰 杨朋范 |
| |
| 作者单位： | [1]福建医科大学福总临床医学院,福建福州350108 [2]南京军区福州总医院药学科,福建福州350025 [3]南京军区福州总医院神经外科癫痫中心,福建福州350025 |
| |
| 摘 要： | 目的：探讨我国癫痫患者P-糖蛋白基因多态性（C3435T）与抗癫痫药物反应性的关联性。方法：采用PCR--RFLP（聚合酶链反应--限制性片段长度多态性分析）的方法对156例癫痫患者外周血进行分型。其中,耐药组癫痫患者85例,有效组癫痫患者71例。结果：耐药组癫痫患者CC基因型21例,占24.70%;有效组癫痫患者CC基因型19例,占26.76%。两组比较无显著差异性。结论：本研究未发现P-gp C3435T基因型与癫痫耐药的关联性。
|
| 关 键 词： | P-糖蛋白 癫痫 基因多态性 |
Association of C3435T Polymorphism in Multidrug Resistance Gene 1 with Refractory Epilepsy |
| |
| WANG Xiao-yan,LIN Ruo-fei,SHI Dao-hua,BAI Zhi-feng,YANG Peng-fan.Association of C3435T Polymorphism in Multidrug Resistance Gene 1 with Refractory Epilepsy[J].Biomagnetism,2011(14):2717-2719. |
| |
| Authors: | WANG Xiao-yan LIN Ruo-fei SHI Dao-hua BAI Zhi-feng YANG Peng-fan |
| |
| Institution: | 1 Fuzhou General Clinical Medical College of Fujian Medical University,Fuzhou,Fujian,350108,China; 2 Department of Pharmacy,Fuzhou General Hospital of Nanjing Military Command,Fuzhou,Fujian,350025,China; 3 Department of Neurosurgery Epilepsy Center,Fuzhou General Hospital of Nanjing Military Command,Fujian,350025) |
| |
| Abstract: | Objective： To discuss the association between the P-glycoprotein gene polymorphism and the efficacy of epilepsy drug.Methods： Genotypes of the C3435T polymorphism were determined by the polymerase chain reaction restriction fragment length poly-morphism（PCR-RFLP） methods in 156 patients,Including refractory epilepsy group（85） and drug-responsive group（71）.Results： In non responders,21 patients were CC genotype（24.70%）.In responders,19 patients were CC genotype（26.76%）.Conclusion： There is no as-sociation between the P-gp C3435T gene polymorphism and the response to antiepileptic drug treatment in Chinese patient with epilepsy. |
| |
| Keywords: | P-glycoprotein Epilepsy Polymorphism |
| 本文献已被 维普 等数据库收录！ |
|
