糖耐量减低患者血清瘦素与内皮素-1的测定及其临床意义

目的：探讨糖耐量减低（IGT）患者血清瘦素（Leptin）和血浆内皮素-1（ET-1）含量变化及其意义。方法：采用放射免疫法检测65例IGT患者、50名正常健康体检者和50例2型糖尿病患者血清中Leptin和ET-1的含量,同时分别测定体重指数、腰臀比、空腹血糖（FBG）、餐后2小时血糖（2h PBG）及空腹胰岛素（FINS）,并用HOMA稳态模型计算胰岛素抵抗指数（HOMA-IR）。结果：糖尿病组、IGT组血清Leptin、ET-1、FBG、2hPBG、FINS、TC含量及HOMA-IR指数显著高于正常对照组（P〈0.05）,糖尿病组血清Leptin、ET-1、FBG、2hPBG、FINS、TC含量及HOMA-IR指数明显高于IGT组（P〈0.05）。IGT组血清Leptin水平与BMI、血清ET-1、FBG、2hPBG、FINS、TC含量及HOMA-IR指数呈显著正相关（P〈0.01）,IGT组血清ET-1水平与收缩压、舒张压、BMI、血清FBG、2hPBG、FINS含量及HOMA-IR指数呈显著正相关（P〈0.01）。结论：瘦素与内皮素-1均可能在IGT发展成2型糖尿病过程中起一定的作用。

The significance of serum level of Leptin and ET-1 in patients with impaired glucose toleranc

Objective：To investigate the significance of serum level of Leptin and ET-1 in patients with impaired glucose toleranc（IGT）.Methods：Serum level of Leptin and ET-1 in 65 patients with IGT,50 subjects with healthy people,and 50 patients with type 2 diabetes mellitus（DM）were detected by ELISA.Body mass index（BMI）,WHR,FBG,2h PBG and FINS were detected.The insulin resistance by homeostasis model assessment（HOMA-IR） was calculated.Results：Serum level of Leptin,ET-1,FBG,2hPBG,FINS,TC and HOMA-IR in DM group and IGT group were higher than those in the control group.Serum level of Leptin,ET-1,FBG,2hPBG,FINS,TC and HOMA-IR in DM group were higher than those in IGT group.Serum level of Leptin in IGT group were correlated with BMI,while the serum level of ET-1,FBG,2hPBG,FINS,TC and HOMA-IR.Serum level of ET-1 in IGT group were correlated with SBP,DBP,BMI,serum level of FBG,2hPBG,FINS and HOMA-IR.Conclusions：Serum level of Leptin and ET-1 may play a role in the pathogenesis from IGT to type 2 diabetes.