靖江地区宫颈病变患者高危型人乳头瘤病毒感染及其基因型分析

目的：研究靖江地区各组宫颈病变中高危型人乳头瘤病毒（HPV）感染率及其基因型分布。方法：采用实时荧光PCR检测方法检测334例宫颈脱落细胞标本中高危型HPV及其基因型。结果：高危型HPV在宫颈炎组、湿疣组、低度鳞状上皮细胞内病变（LSIL）组、高度鳞状上皮细胞内病变（HSIL）组中的感染率分别为24.2%、58.2%、49.3%、69.5%;HPV 16、18、33、58型在宫颈病变中是最常见的HPV型别,其中,HPV16型在宫颈炎组、湿疣组、LSIL组、HSIL组中所占比例逐渐增高,分别为17.9%、18.9%、30.8%、41.9%。结论：高危型HPV感染率随着宫颈病变程度的加重而升高,HPV16型是高危型HPV感染中的主要亚型,HPV18、33、52、58也较常见,其余型别很少。

Infection Rate Human Papilloma Virus and Genotype Distribution of Patients with Cervical Lesions in Jingjiang Area

Objective：To study the infection rate of human papilloma virus and genotype distribution of patients with cervical lesions in Jingjiang area.Methods：Detect the high-risk HPV types and genotype in 334 cervical specimens of routine Pap with Real-Time PCR.Results：The infection rate of high-risk HPV types in cervicitis group,condyloma group,LSIL group,HSIL group was 24.2%,58.2%,49.3%,69.5%,respectively.The most common genotype in cervical lesions is HPV 16,18,33,58;in which,the infection rate of HPV16 in cervicitis group,condyloma group,LSIL group,HSIL group was 17.9%,18.9%,30.8%,41.9%,respectively.Conclusion：The infection rate of high-risk HPV increases with the severity of cervical lesions.HPV16 is the main genotype of the high-risk HPV infection.The other HPV types are more common.