MUC16对子宫内膜容受性的影响及其意义

目的：多囊卵巢综合征（Polycystic Ovary Syndrome,PCOS）系由于体内复杂的内分泌和代谢环境影响了子宫内膜稳态,导致子宫内膜容受性下降,造成患者生育力减弱和不良妊娠结局。通过测定多囊卵巢综合征患者子宫内膜与正常生育力妇女增生期、分泌早、中、晚期子宫内膜中MUC16的相对表达量,本文探讨MUC16与PCOS患者子宫内膜容受性下降的关系,为临床上改善PCOS患者子宫内膜容受性,提高PCOS患者的妊娠率,降低流产率提供一条新的可能途径。方法：选择PCOS患者子宫内膜、正常生育力妇女增生期、分泌早、中、晚期子宫内膜各20例,用免疫组化SP法检测MUC16在各组的表达情况。结果：（1）MUC16在月经周期各期均有表达,在分泌中期表达最强。（2）PCOS组MUC16的表达较分泌中期组弱,差异有显著性（P〈0.05）。结论：（1）在子宫内膜中的表达呈周期性变化。（2）PCOS患者子宫内膜中MUC16表达异常可能使子宫内膜容受性下降,推测其与胚胎不能正常着床或着床后发育不良、导致流产有关。

Expression of MUC16 in Human Endometrium with Polycystic Ovary Syndrome and Normal Endometrial Tissues

Objective： To explore the expression and changes of MUC16 in human normal and polycystic ovary syndrome（PCOS） endometrium during menstrual cycle.Methods： Immunohistochemistry was used to detect the level of MUC16 protein in normal endom-etrium from 80 women and PCOS endometrium from 20 women.Results： MUC16 protein mainly expressed on the top surface of endom-etrium epithelial cells and adenocytes in proliferative phase and secretory phase.The level of MUC16 protein in mid-secretory phase were higher than those in proliferative phase,early and late secretory phase（P0.05）.MUC16 protein expression in PCOS group were significantly lower than those in mid-secretory phase（P0.05）.Conclusion： MUC16 expressions in endometrium are changed in menstrual cycle,which is probably play a role in the establishment of endometrium receptivity and embryo implantation.