癫痫持续状态的发病危险因素分析

目的：探讨癫痫持续状态的发病危险因素。方法：对西京医院神经内科2000年1月至2009年11月连续登记住院的癫痫持续状态患者的临床资料进行回顾性分析，采用条件logistic回归方法筛选癫痫持续状态的危险因素。结果：共收集98例癫痫持续状态患者，一般情况显示：男性发病率明显高于女性，成人发病率明显高于儿童，CSE发生率明显高于NCSE；logistic回归结果显示：中枢神经系统感染（OR值为4．74）为SE的主要危险因素，其次为脑血管病（OR值为3．93）和颅脑外伤（OR值为1．84）。SE发作的有明显诱因的占19例，其中上呼吸道感染伴发热者比例较高。结论：中枢神经系统感染、脑血管病、脑外伤是癫痫持续状态最主要的危险因素，急性上呼吸道感染伴发热者最常见的诱因。预防感染、防治脑血管病、避免外伤，减少各种诱因是预防本病的关键。

Analysis of Risk Factors in Stares Epilepticus Patients

To investigate the risk factors of Status Epilepticus. Methods： Retrospective analysis was used to analyze the clinical data of SE patients from Department of Neurology of Xijing Hospital between January 1999 and November 2009. Logistic regression analysis was performed to determine significant contributors to SE. Results： 98 cases of SE patients were chosen, the data shows that men, adult and CSE patients are at higher risk than that of women, children and NCSE respectively. Logistic regression shows that the main risk factors for SE were central nervous system infections（OR of 4.74）, cerebro-vascular diseases（OR of 3.93）,brain injury （OR of 1.84）. Conclusion： The main risk factors of Status Epilepticus are central nervous system infections, cerebro-vascular diseases and trauma. The upper respiratory infection with fever may be the most frequently incentive of Status Epilepticus in patients with epilepsy history. To avoid the trauma, prevent infection, adhere to take antiepileptic drugs in epilepticus patients, reduce various adverse incentives are the key measures to prevent SE.