趋化因子CXCL12及其受体CXCR4在胶质瘤中的研究进展

CXCL12是趋化因子家族成员之一,是能够特异性结合其受体CXCR4发挥趋化性作用的细胞因子。最初,CXCL12及CXCR4被发现于炎症细胞,参与机体炎症、免疫等病理反应。接下来的几年中发现,它在机体发育、成熟过程中也有重要作用。如今,大量研究表明它与肿瘤的生长、侵袭及转移密切相关。据报道,在乳腺癌、肺癌、卵巢癌等二十余种肿瘤组织中发现CXCL12及CXCR4的表达,其中也包括中枢系统肿瘤-胶质瘤。CXCL12/CXCR4参与胶质瘤生长过程的多个步骤,包括肿瘤增殖、侵袭、转移等。有实验指出,转移灶的CXCR4表达水平较原发灶高,CXCR4有可能成为抑制胶质瘤生长、转移的重要靶目标。

Progress of chemokine CXCL12 and its receptor CXCR4 in glioma

CXCL12 is a member of the chemokine family,is a cytokine can specifically bind to its receptor CXCR4 play a role in chemotaxis.Initially,CXCL12 and CXCR4 wal found in leucocyte,involved in inflammatory or immune responses.The next few years,they were found to play a important role in organism development and maturation.Now,numerous studies found that they were closely related with tumor growth,invasion and metastasis.It is reported that,they express in nearly 20 kinds of tumors such as breast caner,lung cancer,ovarian cancer,and CXCR4 is the most widely expressed cytokine receptor in the tumor.The glioma express CXCL12 and CXCR4 too,they participate in the process of tumor growth,including the proliferation,invasion and metastasis.Some experiments show that CXCR4 expressed in metastasis is higher than primary,it islikely to be a major target inhibting the glioma growth and metastasis.