TNRC9基因rs12443621A/G多态性与中国女性乳腺癌易感性及临床病理关系的研究 |
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引用本文: | 贾雷,李扬,孙梅,崔伟,宋振迪.TNRC9基因rs12443621A/G多态性与中国女性乳腺癌易感性及临床病理关系的研究[J].生物磁学,2011(8):1476-1478. |
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作者姓名: | 贾雷 李扬 孙梅 崔伟 宋振迪 |
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作者单位: | [1]青岛大学,山东青岛266071 [2]青岛市东部市立医院普外科,山东青岛266071 |
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摘 要: | 目的:研究TNRC9/LOC643714基因rs12443621A/G多态性与乳腺癌易感性及临床病理之间的关系。方法:DNA试剂盒提取321例乳腺癌患者和340例正常女性静脉血全基因组DNA,PCR扩增目的基因片段,提取扩增样本进行DNA测序检测分析rs12443621多态性。应用SPSS17.0软件对实验结果进行统计学分析。结果:应用SPSS17.0软件对TNRC9/LOC643714基因rs12443621A/G多态性AA、AG、GG进行卡方检验分析,结果显示三种基因型分布在病例组及对照组中无统计学意义(X2=1.43,P〉0.05),与乳腺癌易感性无关,与乳腺癌病理分型、ER、PR、HER-2状态以及淋巴结是否转移无相关性(X2=2.90,P〉0.05;X2=2.25,P〉0.05;X2=1.671,P〉0.05;X2=1.34,P〉0.05;X2=3.24,P〉0.05)。结论:TNRC9基因rs12443621A/G多态性与乳腺癌易感性及临床病理特征无关,不能作为独立的基因标志物对乳腺癌进行早期检测和诊断。
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关 键 词: | 乳腺癌 易感性 单核苷酸多态性 TNRC9基因 rs12443621 |
Implication of the TNRC9 rs12443621A/G Polymorphisms in BreastCancer in Chinese Women |
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Institution: | JIA Lei,LI Yang,SUN Mei,CUI Wei,SONG ZH-Di(1 Qingdao University Qingdao 266003,China;2 Department of General Surgery,Qingdao municipal HospitalQingdao 266003,China) |
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Abstract: | Objective: To investigate the relationship between the rs12443621 polymorphisms of TNRC9/ LOC643714 and breast cancer risk and clinico-pathological characteristics in Chinese women.Methods: Genomic DNA was extracted from peripheral blood.The Single Nucleotide Polymorphisms of the TNRC9/LOC643714 rs12443621,from breast cancer of 321 cases and 340 controls,were detected by polymerase chain reaction(PCR) and direct DNA sequencing.Results: The genotypes of rs12443621 can not increase the risk for breast cancer(X2=1.43,P0.05).There was no relationship between the genotypes and pathological category,lymph node metastases,ER status or PR status or Her-2 status(X2=2.90,P0.05;X2=2.25,P0.05;X2=1.671,P0.05;X2=1.34,P0.05;X2=3.24,P0.05).Conclusion: There was no relationship between three genotypes of rs12443621A/G and individual susceptibility or clinic pathological characteristics of breast cancer. |
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Keywords: | Breast cancer Liability Single Nucleotide Polymorphisms TNRC9 gene rs12443621 |
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