姜黄素对抗高脂饮食诱导SD大鼠血脂水平升高及改善血管内皮依赖性舒张功能的研究

目的：观察高脂饮食对SD大鼠血脂水平及胸主动脉环舒张功能的影响及姜黄素对以上改变的影响。方法：健康SD大鼠30只,分高脂饮食组（10只）、正常饮食对照组、高脂饮食＋姜黄素组（10只）,大鼠行适应性饲养1周后分别给予高脂饮食及正常饮食;于实验开始时、10周及实验结束前测各组大鼠体重,20周后取血测定血清血脂浓度,取胸主动脉测定血管环舒张功能。结果：①高脂饮食喂养的大鼠体重明显高于其他各组大鼠,姜黄素可明显对抗高脂饮食导致的体重升高。②与对照组比较,高脂饮食组TC、TG、LDL-C明显升高（P〈0.01和P〈0.05）;③与正常对照组及姜黄素对照组比较,高脂饮食组胸主动脉环的内皮依赖性舒张功能显著减弱（P〈0.05）。结论：①SD大鼠给予高脂饮食后使大鼠血脂水平明显升高,胸主动脉环内皮依赖性舒张功能显著减弱。②姜黄素具有防治高脂饮食导致的血脂升高及改善高脂饮食导致的血管内皮依赖性的舒张功能减退。

Effect of Curcumin on High Blood Lipid Levels of Rats Induced by High-Fat Diet and Endothelium-Dependent Vasodilation Function of Thoracic Aorta

Objective：To observe the effects of curcumin to the blood lipid level and the endothelium-dependent vasodilation function of Thoracic aorta of SD rat＇s feed with high fat diet.Methods：30 SD rats were divided into three groups randomly：10 feed with high-fat diet,10 feed with normal diet,10 feed with high fat diet and curcumin,rats were given adaptive feeding for 1 week,at the begin-ning of the experiment,10 weeks and the end of the experiment the rats body weight were measured,after 20 weeks the blood serum lipid concentrations and aortic vascular function were measured.Results：① The body weight of rats fed high fat diet was significantly higher than other rats,curcumin lower the body weight induced by high fat diet significantly.② Compared with control group,high fat diet group TC,TG,LDL-C was significantly higher than the other groups（P 0.01or P 0.05）;③compared with the control group and the curcumin control group,high fat diet group＇s aortic ring endothelium-dependent dilation was significantly reduced（P 0.05）.Conclusions：① SD rats＇s blood lipid that given high fat diet significantly higher than the other group,and the thoracic aorta endothelial function was significantly reduced.② curcumin reduced the elevated blood lipids caused by high fat diet and high fat diet caused the endothelium-de-pendent relaxation of vascular dysfunction.