瑞舒伐他汀对兔心肌梗死后心室重构及细胞凋亡的影响

目的：观察瑞舒伐他汀对新西兰大白兔心肌梗死后左室重构及心肌细胞凋亡的影响。方法：45只雄性新西兰大白兔随机分成三组，即：假手术组（S，n=15），心肌梗死对照组（MI，n=15），心肌梗死瑞舒伐他汀干预组（R，n=15）。MI组和R组大鼠结扎左冠状动脉前降支建立AMI模型。心肌梗死对照组及假手术组术后24h灌等量的生理盐水．．瑞舒伐他汀干预组于术后24h直接灌胃法给药，给药剂量以10mg／kgtd计算。干预2周后，进行心脏超声测定，随即处死新西兰大白兔、取出心脏，观察病理组织形态，并通过Westernblot方法检测Bcl-2，Bax在心肌梗死边缘区的蛋白表达。结果：①心脏超声检测表明干预组左室舒张末内径（LVEDD）、左室收缩末内径（LVESD）较心肌梗死对照组降低而左室射血分数（LVEF）较心肌梗死对照组增高。②干预组心肌梗死边缘区Bax表达与心肌梗死对照组比较未见统计学差异，而Bcl一2表达高于心肌梗死对照组。结论：瑞舒伐他汀上调Bcl一2的表达，改善心室重构。

Effects of Rosuvastatin on Ventricular Remodeling and Cardiomyocyte Apoptosis after Acute Myocardial Infarction in Albino Rabbit Model

Objeetive： To investigate the effects of rosuvastatin on ventricular remodeling and cardiomyocyte apoptosis after myocardial infarction. Methods： A total of 45 male New Zealand albino rabbits were randomly divided into three groups： sham operation group（S,n= 15）, AMI control group（MI,n= 15） and AMI rosuvastatin intervention group（R,n= 15）.AMI models were made with the ligation of left anterior descending coronary artery in MI and R group. Rabbits in R group were administered rosuvastatin via direct gastric gavage 24 hours after the ligation according to 10mg/kg＊d ;while rabbits in the other two groups were administered distilled water of the same volume also by gastric gavage for two weeks. All the rabbits were immediately killed after transthoracic echocardiography ,and their hearts were taken out,observing the pathomorphological change （HE）, measuring the expressions ofBax, Bcl-2, by western blot. Results： （1） Transthoracic echocardiography showed that left ventricular end diastolic diameter （LVEDD）, left ventricular end systolic diameter （LVESD） in Group R were smaller than those of Group MI ,but left ventricular ejection fraction （LVEF） were significantly increased. （2） Western blot showed that there were no significant differences between Group R and Group MI in the expression of Bax,however, Bcl-2 expression was increased significantly in Group R. Conclusion： Rosuvastatin increases the expression of Bcl-2 and improves the ventricular remodeling of rabbits.