Sodium butyrate enhances the cytotoxic effect of cisplatin by abrogating the cisplatin imposed cell cycle arrest |
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| Authors: | Miglena Koprinarova Petya Markovska Ivan Iliev Boyka Anachkova George Russev |
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| Institution: | (1) Bulgarian Academy of Sciences, Institute of Molecular Biology, Acad. G. Bonchev Street, block 21, 1113 Sofia, Bulgaria;(2) Bulgarian Academy of Sciences, Institute of Experimental Pathology and Parasitology, Acad. G. Bonchev Street, block 25, 1113, Sofia, Bulgaria |
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| Abstract: | Background Histone deacetylase inhibitors have been proposed as potential enhancers of the cytotoxic effect of cisplatin and other anticancer
drugs. Their application would permit the use of lower therapeutic doses and reduction of the adverse side effects of the
drugs. However, the molecular mechanisms by which they sensitize the cells towards anticancer drugs are not known in details,
which is an obstacle in developing effective therapeutic protocols. |
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