Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases |
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| Authors: | Eleanor I Ager Way W Chong Shu-wen Wen Christopher Christophi |
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| Affiliation: | (1) Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia |
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| Abstract: | Background Blockade of the angiotensin (ANG) II type 1 receptor (AT1R) inhibits tumour growth in several cancers, including colorectal cancer (CRC) liver metastases. While AT1R blockade has been extensively studied, the potential of targeting the antagonistically acting AT2R in cancer has not been investigated. This study examined the effect of AT2R activation with the agonist CGP42112A in a mouse model of CRC liver metastases. |
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