Excision dynamics of <Emphasis Type="Italic">Vibrio</Emphasis> pathogenicity island-2 from <Emphasis Type="Italic">Vibrio cholerae:</Emphasis> role of a recombination directionality factor VefA |
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| Authors: | Salvador Almagro-Moreno Michael G Napolitano E Fidelma Boyd |
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| Institution: | 1.Department of Biological Sciences,University of Delaware,Newark,USA;2.Dartmouth Medical School, Dept. of Microbiology and Immunology,Hanover,03755 |
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| Abstract: | Background
Vibrio Pathogenicity Island-2 (VPI-2) is a 57 kb region present in choleragenic V. cholerae isolates that is required for growth on sialic acid as a sole carbon source. V. cholerae non-O1/O139 pathogenic strains also contain VPI-2, which in addition to sialic acid catabolism genes also encodes a type
3 secretion system in these strains. VPI-2 integrates into chromosome 1 at a tRNA-serine site and encodes an integrase intV2 (VC1758) that belongs to the tyrosine recombinase family. IntV2 is required for VPI-2 excision from chromosome 1, which occurs
at very low levels, and formation of a non-replicative circular intermediate. |
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