Genomic instability in chidren born after the Chernobyl Nuclear Accident (in vivo and in vitro studies) |
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Authors: | A V Aghajanyan I I Suskov |
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Institution: | (1) Russian Institute of Agricultural Radiology and Agroecology, Kievskoe shosse109 km, 249030 Obninsk, Russia;(2) Korea Atomic Energy Research Institute, 150 Deokjin-dong, Yuseong-gu, Daejeon, 305-353, South Korea |
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Abstract: | Analysis of peripheral blood lymphocytes in children born after the accident at the Chernobyl Nuclear Power Plant in the period
from 1987 to 2004 (permanent residents of territories contaminated with radionuclides, n = 92; and children of irradiated fathers-liquidators, n = 88) revealed increased levels of aberrant cells (ACs) and aberrations of the chromosomal type as compared to the control
(P < 0.05). In three subgroups of children with different initial AC frequencies (children with high AC frequencies, ≥3%; children
with medium AC frequencies, 2%; and children with low AC frequencies, ≤1%), the levels of aberrations of the chromosomal type
are increased as compared to the control (P < 0.05). The levels of aberrant cells and chromosome aberrations (CAs) in the subgroup of children with ≥3% frequencies significantly
differ from those in the subgroup of children with ≤1% AC frequencies. No dependence of the AC and CA frequencies on the year
of birth after the Chernobyl accident was revealed. After fractional and single γ-irradiation (137Cs) of blood in vitro in
the 10–30 cGy dose range, the average CA frequencies in the first and second mitoses increased in a similar way depending
on the initial AC frequencies in the children and parents. All these results suggest an individual character of genomic instability
induced by low radiation doses and its transgenerational phenomenon in the organisms of children. |
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