Protein complex forming ability is favored over the features of interacting partners in determining the evolutionary rates of proteins in the yeast protein-protein interaction networks |
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Authors: | Sandip Chakraborty Bratati Kahali Tapash C Ghosh |
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Institution: | 1.Bioinformatics Centre, Bose Institute,Kolkata,India |
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Abstract: | Background Evolutionary rates of proteins in a protein-protein interaction network are primarily governed by the protein connectivity
and/or expression level. A recent study revealed the importance of the features of the interacting protein partners, viz., the coefficient of functionality and clustering coefficient in controlling the protein evolutionary rates in a protein-protein
interaction (PPI) network. |
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