人类免疫缺陷病毒-1进入细胞的分子机制及相关药物的研究

艾滋病（AIDS）是由人类免疫缺陷病毒（HIV）侵染表达CD4表面抗原（CD4⁺）的T淋巴细胞而引起的.艾滋病病毒进入CD4⁺T淋巴细胞首先是通过病毒与细胞膜的融合来完成的.该融合过程涉及到病毒表面膜蛋白（gp120和gp41）与细胞表面受体蛋白（CD4和CCR5等）之间的相互作用.根据对这些蛋白质分子结构及作用机制的认识，从破坏病毒与细胞的融合入手，设计新型的抗艾滋药物及疫苗，已成为目前药物开发的新热点.

Molecular Mechanism of The Entry of HIV-1 into Cells and The Related Drug Research

The human immunodeficiency viruses(HIV) cause the destruction of CD4 lymphocytes, resulting in the development of acquired immunodeficiency syndrome (AIDS). The entry of HIV into host cells is mainly mediated by the fusion of the viral and cellular membranes, which involves the interactions of a series of biomacromolecules, such as gp120,gp41,CD4 and CCR5. The deep understanding of the crystal structures, the surfactant details of their interaction, and the change of conformation during interaction of the macromolecules provides a new idea for the anti HIV drugs. At present some new drugs have been found arising from this idea.