Chemical synthesis of a tetradecamer in the deoxyribonucleic acid series |
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Authors: | M S Poonian E F Nowoswiat L Tobias A L Nussbaum |
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Institution: | Chemical Research Department, Hoffmann-La Roche Inc., Nutley, New Jersey 07110 USA |
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Abstract: | The chemical synthesis of a tetradecadeoxyribonucleotide, d-EtSp(A-T-G-G-A-A-A-C-T-G-C-G-G-C), is described. This oligomer, designated Fragment 4δ, constitutes the 5′-terminus of the plus strand of a projected duplex coding for S-Peptide2–14 derived from Ribonuclease A. The Fragment was constructed by block condensation via a phosphorothioate anchor. Complications due to inadvertent phosphotriester condensations are discussed. Arguments justifying the sequence selection are presented. |
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