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The O-polysaccharide of Escherichia coli O112ac has the same structure as that of Shigella dysenteriae type 2 but is devoid of O-acetylation: a revision of the S. dysenteriae type 2 O-polysaccharide structure |
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| Authors: | Perepelov Andrei V Weintraub Andrej Liu Bin Senchenkova Sof'ya N Shashkov Alexander S Feng Lu Wang Lei Widmalm Göran Knirel Yuriy A |
| Institution: | N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation. perepel@ioc.ac.ru |
| Abstract: | The O-antigen structure of Shigella dysenteriae type 2 was reinvestigated using chemical modifications along with high-resolution 2D (1)H and (13)C NMR spectroscopy. The O-antigen was found to contain a pyruvic acid acetal, which was overlooked in an early study, and the following revised structure of the pentasaccharide repeating unit was established: where approximately 70% GlcNAc residues bear an O-acetyl group at position 3. The O-antigen of Escherichia coli O112ac was found to have the same carbohydrate structure but to lack O-acetylation. |
| Keywords: | Escherichia coli Shigella dysenteriae O-Antigen Bacterial polysaccharide structure Pyruvic acid acetal |
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