Mannose binding lectin plays a crucial role in innate immunity against yeast by enhanced complement activation and enhanced uptake of polymorphonuclear cells |
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| Authors: | Eveline C van Asbeck Andy IM Hoepelman Jelle Scharringa Bjorn L Herpers Jan Verhoef |
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| Affiliation: | (1) Eijkman-Winkler Institute for Medical & Clinical Microbiology, Utrecht University Hospital, Utrecht, the Netherlands;(2) Department of Internal Medicine & Infectious Diseases, Utrecht University Hospital, Utrecht, the Netherlands;(3) Department of Medical Microbiology & Immunology, St. Antonius Hospital Nieuwegein, the Netherlands |
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| Abstract: | Background Mannose binding lectin (MBL) is an important host defence protein against opportunistic fungal pathogens. This carbohydrate-binding protein, an opsonin and lectin pathway activator, binds through multiple lectin domains to the repeating sugar arrays displayed on the surface of a wide range of clinically relevant microbial species. We investigated the contribution of MBL to antifungal innate immunity towards C. parapsilosis in vitro. |
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