Optical resolution by crystallization from melt using enantiomer derivatives as resolving agents: nonlinear behavior of resolving agent mixtures |
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Authors: | Schindler József Egressy Márton Bálint József Hell Zoltán Fogassy Elemér |
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Institution: | Research Group for Organic Chemical Technology, Budapest University of Technology and Economics, Hungary. jschindler@mail.bme.hu |
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Abstract: | Substituted racemic 1-phenylethylamine derivatives were reacted in molten phase with chiral N-substituted 1-phenylethylamine dicarboxylic acid derivatives (4-9), and their mixtures (e.g., 4+6, 7+8, etc.) in different ratios, and the crystalline quasi-racemic diastereomers so formed were separated. Nonlinear behavior of the mixtures of resolving agents having related structure and considerable positive and negative chiral-chiral interactions were observed. |
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Keywords: | resolution enantiomer nonlinear melt related structure |
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