Removing the brakes on cell identity |
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| Authors: | Akerman Ildem van Arensbergen Joris Ferrer Jorge |
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| Affiliation: | Genomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biomèdiques August Pi Sunyer, Barcelona 08036, Spain. |
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| Abstract: | In this issue of Developmental Cell, Dhawan et?al. (2011) show that deletion of the Dnmt1 DNA methyltransferase gene in pancreatic insulin-producing cells makes these cells convert into glucagon-producing cells. This suggests that manipulation of a general epigenetic mechanism may be used to redirect cell fates. |
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