Rnd-ing up RhoA activity to link neurogenesis with steps in neuronal migration |
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| Authors: | Li Jingjun Anton E S |
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| Institution: | UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. |
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| Abstract: | Neurogenesis is integrated with neuronal migration to ensure proper development of the cerebral cortex. Reporting in Neuron, Pacary et?al. (2011) demonstrate that proneural factors activate atypical Rho GTPases Rnd2 and Rnd3 in newborn cortical neurons, leading to compartmentalized modulation of RhoA signaling and differential control of neuronal migration stages. |
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