An improved synthesis of 10,11-didehydro Cinchona alkaloids |
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Authors: | Kacprzak Karol M Lindner Wolfgang Maier Norbert M |
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Institution: | Department of Analytical Chemistry and Food Chemistry, University of Vienna, Vienna, Austria. |
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Abstract: | A revised procedure for the conversion of the four major Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) into their respective 10,11-didehydro derivatives is described. The reported protocol offers several advantages over a recently published synthetic route. These include (i) enhanced robustness (ii) ready scalability (iii) reduced operational complexity and number of steps (iv) chromatography-free work-up. In addition, toxic solvents were replaced by environmentally less problematic alternatives. |
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