Prostaglandins, cyclic nucleotides and cell function |
| |
Authors: | Frederick A. Kuehl Jr. |
| |
Affiliation: | Department of Basic Medical Sciences Merck Institute for Therapeutic Research Rahway, New Jersey 07065, USA |
| |
Abstract: | Based upon the ability of the E-prostaglandins to stimulate cyclic AMP formation in a dose-related manner and the correlation between this property and their affinity for a membraneous receptor, the action of these prostaglandins was proposed to be expressed largely via cyclic AMP. The failure of the F-prostaglandins to demonstrate significant activity in these two parameters led to the suggestion that they must act at another receptor via a different mediator. The recent isolation of a receptor unique to PGF2α and the demonstrated ability of this prostaglandin to increase tissue cyclic GMP levels are consistent with this concept that the E-prostaglandins and PGF2α play distinctly different roles in cell regulation. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|