An update on the role of miRNA-155 in pathogenic microbial infections |
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| Affiliation: | 1. The State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha 410078, Hunan, China;2. International Centre for Genetic Engineering and Biotechnology, Area Science Park, Padriciano 99, 34012 Trieste, Italy;1. Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil;2. Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil;3. Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil;1. Maanshan Center for Clinical Laboratory, Maanshan Municipal Hospital Group, 45, Hubei Road, 243000 Maanshan, China;2. Molecular Medicine & Tumor Research Center, Chongqing Medical University, Chongqing, China;1. Department of Microbiology, MGM Institute of Health Sciences, Kamothe, Navi Mumbai, 410209, India;2. Molecular and Cellular Biology Laboratory, National Institute for Research in Reproductive Health, J.M. Street, Parel, Mumbai, 400012, India;1. Department of Cancer Biology, Biochemistry Unit, National Cancer Institute, Cairo University, Cairo, Egypt;2. Department of Botany and Microbiology, Faculty of Science, Cairo University, Cairo, Egypt;3. Department of Medical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt;4. Department of Pathology, National Institute of Urology and Nephrology, Cairo, Egypt;5. Department of Pathology, Sinai University, Al-Arish, Egypt |
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| Abstract: | MicroRNAs (miRNAs) are evolutionarily conserved and naturally abundant molecules of single-stranded, non-coding RNA from ∼17 to 25 nucleotides long. MiRNAs act at post-transcriptional level either to suppress gene translation or to induce mRNA degradation, according to the degree of complementarity with their target sequences. MiR-155 is a typical representative of the miRNA family that plays a crucial role in cell differentiation and organism development. A number of studies have shown that miR-155 can not only regulate cell proliferation, apoptosis and lymphoma progression, but also plays an important part in various other physiological and pathological processes. For instance, it is involved in hematopoietic cell differentiation, cardiovascular disease, inflammation and immune responses. In recent years, the role of miR-155 in infectious diseases has attracted considerable attention. This review will highlight the participation of miR-155 in the responses to infections caused by different pathogens. |
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| Keywords: | miR-155 Viral infection Bacterial infection Host cells |
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