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Noninvasive fetal genomic,methylomic, and transcriptomic analyses using maternal plasma and clinical implications
Affiliation:1. Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan 250021, China;2. School of Nursing, Shandong University, 44 Wenhua Road, Jinan 250012, China;3. School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China;4. School of Biomedical Sciences Core Laboratory, The Chinese University of Hong Kong Shenzhen Research Institute, 10 Yuexing Erdao, Nanshan District, Shenzhen 518000, China;5. Center for Reproductive Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, 145 Middle Shandong Rd, Shanghai 200001, China;1. Department of Biology, School of Life Sciences, Anhui Medical University, Hefei 230032, China;2. Department of Pathology, Anhui Medical University, Hefei 230032, China;3. State Key Laboratory & Incubation Base of Dermatology of Ministry of National Science and Technology, Anhui Medical University, Hefei 230032, China;4. Sektion Experimentelle Anaesthesiologie, Universitaetsklinikum Ulm, Ulm 89081, Germany;5. MVZ, ACURA Kliniken, Baden-Baden 76530, Germany;6. Clinical Laboratory, the First Affiliated Hospital, Anhui Medical University, Hefei 230032, China
Abstract:
Keywords:noninvasive prenatal diagnosis  fetal epigenome  fetal transcriptome  massively parallel sequencing  cell-free DNA
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