Smart design of fiber optic surfaces for improved plasmonic biosensing |
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| Institution: | 1. Proteomics and Microbiology Laboratory, University of Mons, Mons, Belgium;2. Electromagnetism and Telecommunication Department, University of Mons, Mons, Belgium;1. Department of Biological Science, University of Alabama at Huntsville, Huntsville, AL 35899, USA;2. Center for Applied Optics, University of Alabama at Huntsville, Huntsville, AL 35899, USA;3. Department of Nanoscience, Joint School of Nanoscience and Nanoengineering, University of North Carolina at Greensboro, Greensboro, NC 27401, USA;4. Department of Electrical and Computer Engineering, University of Alabama at Huntsville, Huntsville, AL 35899, USA;1. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;2. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China;3. School of Environmental Science and Engineering, Tianjin University, Tianjin 300072, China;4. Research Center of Hunan Entry–Exit Inspection and Quarantine Bureau, Changsha 410001, China;1. Nanobiosensors and Bioanalytical Applications Group (NanoB2A), Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and the Barcelona Institute of Science and Technology, 08193 Bellaterra, Barcelona, Spain;2. CIBER-BBN Networking Center on Bioengineering, Biomaterials and Nanomedicine, Spain;3. Protein Alternatives, S.L., Tres Cantos, Madrid, Spain;1. Chongqing Key Laboratory of Optical Fiber Sensor and Photoelectric Detection, Chongqing University of Technology, Chongqing 400054, China;2. School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China;3. School of Opto-electronic Information, University of Electronic Science and Technology of China, Chengdu 610054, China |
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| Abstract: | Although the phenomenon of surface plasmon resonance (SPR) is known for more than a century now, traditional prism-based SPR platforms have hardly escaped the research laboratories despite being recognized for the sensitive and specific performance. Significant efforts have been made over the last years to overcome their existing limitations by coupling the SPR phenomenon to the fiber optic (FO) technology. While this platform has been promoted as cost-effective and simpler alternative capable of handling label-free bioassays, quantification and real-time monitoring of biomolecular interactions, examples of its applicability in sensing and biosensing remain to date very limited. The FO-SPR system is still in development and requires further advancements for reaching the stability and sensitivity of the benchmark SPR systems. Among existing strategies for device improvement, those based on modifying the FO tips using nanomaterials are mostly studied. These small-scale objects provide a wide range of possibilities for alternating the architecture of the FO sensitive zone, enabling also unique effects such as localized SPR (LSPR). This mini-review summarizes the latest innovations in the fabrication procedures which use nanoparticles or other nanomaterials, aiming at FO-SPR technology performance improvements, as well as addition of new device features and functionalities. |
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