Association Of Peripheral 5-Hydroxyindole-3-Acetic Acid,A Serotonin Derivative,with Metabolic Syndrome and Low-Grade Inflammation |
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| Institution: | 1. From the Division of Surgical Oncology, Baylor Scott & White Health, Texas A&M Health Science Center;2. Department of Surgery, UT Southwestern Medical Center;3. Endocrine Surgery, John Wayne Cancer Institute at Providence St. John''s Health Center;4. Department of Surgery, Oregon Health and Sciences University;5. Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center;6. Department of General and Endocrine Surgery, Emory University School of Medicine;7. Department of Endocrine, Moffitt Cancer Center;8. Department of Surgery, Memorial Sloan-Kettering Cancer Center;9. Thyroid & Parathyroid Surgical Divisions, General Otolaryngology, Harvard Medical School.;1. From the Departments of Endocrine Surgery, Cleveland Clinic, Cleveland, Ohio.;2. Clinical Pathology, Cleveland Clinic, Cleveland, Ohio.;3. Endocrinology, Cleveland Clinic, Cleveland, Ohio. |
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| Abstract: | Objective: The constellation of metabolic abnormalities seen in metabolic syndrome (MetS) has been linked to atherosclerosis and adverse cardiovascular outcomes due to heightened inflammation. Accumulating evidence suggests that peripheral 5-hydroxyindole-3-acetic acid (5-HIAA), the derivative end-product of serotonin (5-HT), might be involved in the pathogenesis of obesity, and abnormal lipid and glucose metabolism. We examined the association between serum 5-HIAA concentrations and MetS and also highly sensitive C-reactive protein (hsCRP).Methods: We assessed 180 healthy adults (110 males and 70 females) in a cross-sectional setting. Anthropometric indices and blood pressure were measured, as were laboratory parameters including fasting 5-HIAA concentrations. The associations between 5-HIAA and individual components of MetS, as well as MetS as a single entity, were investigated with bivariate correlation and logistic regression analyses.Results: Eighty-nine individuals (49.4%) were diagnosed with MetS. Significant correlations were found between 5-HIAA concentrations and age (r = 0.184), waist circumference (r = 0.415), high-density lipoprotein (HDL) cholesterol (r = -0.148), systolic blood pressure (r = 0.374), diastolic blood pressure (r = 0.355), homeostasis model assessment of insulin resistance (r = 0.201), and hsCRP (r = 0.453) were found (P<.05 in all tests). In logistic regression, 5-HIAA was significantly associated with 4 MetS components including central obesity, raised triglycerides, raised blood pressure, and raised fasting plasma glucose (FPG) (P<.05). Moreover, 5-HIAA was a predictor of MetS as a single entity, and the relationship persisted after adjusting for hsCRP (odds ratio OR] = 4.41, 95% confidence interval CI]: 2.58-7.67, P<.001).Conclusion: Elevated concentrations of 5-HIAA are seen in individuals with MetS. Increased 5-HIAA is also associated with hsCRP, a marker of chronic lowgrade inflammation underlying MetS.Abbreviations: BMI = body mass index CI = confidence interval FI = fasting insulin FPG = fasting plasma glucose HbA1c = glycated hemoglobin HDL = high-density lipoprotein 5-HIAA = 5-hydroxyindole-3-acetic acid 5-HT = 5-hydroxytryptamine HOMA-IR = homeostatic model assessment of insulin resistance hsCRP = highly sensitive C-reactive protein LDL = low-density lipoprotein MetS = metabolic syndrome OR = odds ratio |
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