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Capsular polysaccharide of Group B Streptococcus mediates biofilm formation in the presence of human plasma |
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| Affiliation: | 1. State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People''s Republic of China;2. Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, People''s Republic of China;3. The Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu, People''s Republic of China;4. Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan;5. Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kweishan, Taoyuan, Taiwan |
| Abstract: | Group B Streptococcus (GBS) is an asymptomatic colonizer of human mucosal surfaces that is responsible for sepsis and meningitis in neonates. Bacterial persistence and pathogenesis often involves biofilm formation. We previously showed that biofilm formation in medium supplemented with glucose is mediated by the PI-2a pilus. Here, biofilm formation was tested in cell culture medium supplemented with human plasma. GBS strains were able to form biofilms in these conditions unlike Group A Streptococcus (GAS) or Staphylococcus aureus. Analysis of mutants impaired for various surface components revealed that the GBS capsule is a key component in this process. |
| Keywords: | GBS Streptococcus Biofilm Capsular polysaccharide Human plasma |
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