Thyroid Function and Metabolic Syndrome: A Cross-Sectional Study in Obese and Overweight Patients |
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| Affiliation: | 1. Holland Orthopaedic & Arthritic Centre, Sunnybrook Health Sciences Centre, Toronto, Canada;2. Women’s College Hospital, University of Toronto Orthopaedic Sports Medicine, Toronto, Canada;3. Mount Sinai Hospital, Toronto, Ontario, Canada;1. From the Endocrinology Division, Department of Medicine, National University Hospital, Singapore;2. Yong Loo Lin School of Medicine, National University of Singapore;3. Department of Medicine, Endocrinology Service, Memorial Sloan Kettering Cancer Center, New York, New York;4. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore;5. The Endocrine Clinic, Mount Elizabeth Medical Centre, Singapore. |
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| Abstract: | Objective: Metabolic syndrome (MetS) is associated with increased risks of developing cardiovascular disease and type 2 diabetes. Thyroid dysfunction is also a known cardiovascular risk factor. In obese patients, serum thyroid-stimulating hormone (TSH) levels tend to be higher than in lean controls. The objective of this study was to assess potential associations between serum TSH levels and MetS as well as individual components of MetS.Methods: This was a cross-sectional observational study of obese and overweight patients seen for initial evaluation at the Boston Medical Center weight-management clinic between February 1, 2013 and February 1, 2014. Demographic, anthropometric, and laboratory data including serum TSH, insulin, glucose, hemoglobin A1c, and lipid levels were obtained from electronic medical records. Associations between serum TSH levels and presence of MetS and its components were assessed.Results: A total of 3,447 patients, 75.6% female and 38% African American, without known thyroid dysfunction, were included. Mean ± SD age was 46.74 ± 15.11 years, and mean ± SD body mass index was 36.06 ± 9.89 kg/m2. Among 1,005 patients without missing data, the prevalence of MetS was 71.84%. In patients with MetS, the median serum TSH was 1.41 μIU/mL, compared with 1.36 μIU/mL in patients without MetS (P = .45). In multivariate models, there was no significant association between serum TSH levels and the presence of MetS, adjusting for age, sex, race, education, socioeconomic status, and smoking. There were also no significant associations between serum TSH and individual components of the MetS.Conclusion: Serum TSH level does not appear to be a potentially modifiable risk factor for MetS in obese and overweight individuals.Abbreviations: BMI = body mass index FT4 = free thyroxine HDL-C = high-density-lipoprotein cholesterol HbA1c = hemoglobin A1c MetS = metabolic syndrome SE = standard error TSH = thyroid-stimulating hormone |
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