The Relationship Between Serum 25-Hydroxyvitamin D and Glucose Homeostasis in Obese Children and Adolescents in Zhejiang,China |
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| Institution: | 1. From the Department of Endocrinology, Children''s Hospital of Zhejiang University School of Medicine, Hangzhou, China.;2. Department of Statistics, Children''s Hospital of Zhejiang University School of Medicine, Hangzhou, China.;3. Department of Child Health Care, Children''s Hospital of Zhejiang University School of Medicine, Hangzhou, China.;1. From the Department of Clinical Cell Biology, Chiba University Graduate School of Medicine, Chiba, Japan;2. Center for Diabetes, Metabolism and Endocrinology, Toho University Sakura Medical Center, Chiba, Japan;3. Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan;4. Department of Pathology, Chiba University Graduate School of Medicine, Chiba, Japan.;5. Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan. |
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| Abstract: | Objective: Evidence of the association between vitamin D, insulin resistance, and oral disposition index (oDI) in obese children and adolescents is limited. To fill this research gap, we measured serum 25-hydroxyvitamin D (25[OH]D) levels in obese children and analyzed the relationship between serum 25(OH)D levels and glucose homeostasis.Methods: Altogether, 348 obese and 445 nonobese children and adolescents (age, 6 to 16 years) were enrolled in this study. Obese children were divided into 4 subgroups: normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and combined IFG and IGT (IFG+IGT) according to oral glucose tolerance test results. We measured serum 25(OH)D levels and calculated the homeostasis model assessment (HOMA) of insulin resistance (IR), the whole-body insulin sensitivity index (WBISI), and the disposition index.Results: The levels of 25(OH)D in the obese group were significantly lower than in the nonobese group; serum 25(OH)D level in the NGT subgroup was higher than those of the other 3 subgroups, and it was significantly inversely correlated with logHOMA-IR (r = -0.090; P = .045) and positively correlated with logWBISI and logHOMA-oDI (r = 0.091, P = .049; and r = 0.108, P = .046, respectively). Obese patients with vitamin D deficiency thus have a significantly higher risk of disturbances in glucose metabolism.Conclusion: 25(OH)D deficiency or insufficiency is quite common in obese children and adolescents in Zhejiang, China. Obese patients with 25(OH)D deficiency (<30 nmol/L) are shown to be at higher risk for abnormal glucose metabolism.Abbreviations: 25(OH)D = 25-hydroxyvitamin D ΔI30/ΔG30 = insulinogenic index BMI = body mass index CI = confidence interval HbA1c = hemoglobin A1c HOMA = homeostasis model assessment IF = fasting insulin IFG = impaired fasting glucose IGT = impaired glucose tolerance IR = insulin resistance NGT = normal glucose tolerance oDI = oral disposition index OGTT = oral glucose tolerance test WBISI = whole-body insulin sensitivity index |
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